آرشیو روزانه: 6 خرداد 1402

Physical Characterization, Mechanistic Analysis and you may Framework-Activity Matchmaking of Chemically Stable TLR2 Antagonists

Physical Characterization, Mechanistic Analysis and you may Framework-Activity Matchmaking of Chemically Stable TLR2 Antagonists

Undegraded: The new 1,dos,3-triphenol theme of identified TLR2 antagonists is highly susceptible to oxidation and you may excludes him or her out of use in lengthened experiments around cardiovascular standards. Here, i report an objectively build group of novel TLR modulators ensuing during the compound 6, a novel, chemically secure, nontoxic, TLR2-choosy antagonist.

Abstract

Toll-particularly receptors (TLRs) generate the initial burden regarding the innate immune response and this depict encouraging targets for the modulation of inflammatory procedure. Has just, the fresh new pyrogallol-that has had TLR2 antagonists CU-CPT22 and you will MMG-11 had been said; although not, the 1,2,3-triphenol motif renders him or her highly susceptible to oxidization and you can excludes him or her regarding include in stretched studies around aerobic requirements. Therefore, you will find create some book TLR2 antagonists (1–9) according to the logical adaptation away from substructures, linker issues, and the hydrogen-bonding development of your pyrogallol precursors that with chemically robust strengthening stops.

(بیشتر بخوانید)
توسط 6 خرداد 14020 دیدگاه
خانهدسته بندی هاحساب من
0 سبد خرید
جستجو